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M94A3014.TXT
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1994-10-25
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Document 3014
DOCN M94A3014
TI Effect of interferon alpha 2A on serum androgen in HIV+ men with
Kaposi's sarcoma.
DT 9412
AU Christeff N; Gharakhanian S; Thobie N; Wirbel E; Rozenbaum W; Nunez EA;
U224 INSERM, CHU Bichat, Paris.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):173 (abstract no. PB0120). Unique
Identifier : AIDSLINE ICA10/94369561
AB OBJECTIVE: To compare the serum androgen concentrations of HIV+ men with
Kaposi's sarcoma (KS), before, during and after treatment with
recombinant alpha-2a interferon (INF) (Hoffman-La Roche). We have
detected high serum androgen levels in HIV+ KS men. METHODS: Serum from
22 HIV+ men with KS were analysed for androgens: dehydroepiandrosterone
(DHEA), DHEA sulfate (DHEAs), androstenedione (delta 4), testosterone
(T) by RIA before (1), during (2) and after (3) treatment with INF. The
results were compared 2 versus 1, 3 versus 1 and 2 versus 3 and
interpreted in terms of the clinical remission of KS. RESULTS: All the
patients, except one, were homosexual. TABULAR DATA, SEE ABSTRACT
VOLUME. All androgens concentrations dropped during INF treatment, and
remained low after treatment. The decrease of androgen are for DHEA
-50%, p < 0.01; DHEAs -35%, p < 0.01; delta 4 -40%, p < 0.01 and T -40%,
p < 0.01. 18 of the 22 men treated achieved complete remission of their
HIV-related KS. CONCLUSION: Treatment of HIV+ men suffering from KS with
IFN lowered their serum androgen levels particularly that of DHEA. This
decrease coincided with the complete clinical remission of these
patients. But there was no correlation with the changes in CD4 count.
These data suggest that androgens may be involved in the appearance of
KS and could provide a new therapeutic approach to this syndrome.
DE Androgens/*BLOOD Follow-Up Studies Human HIV
Seropositivity/BLOOD/*THERAPY Interferon Alfa-2a/*THERAPEUTIC USE Male
Sarcoma, Kaposi's/BLOOD/*THERAPY MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).